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IL-17 modulator 3 is a small-molecule IL-17 pathway modulator intended for research use in studies of inflammation, cancer, and autoimmune diseases. It is provided as a chemically characterized research reagent with documentation of purity and structural identifiers suitable for in vitro and preclinical investigations.
High purity (99.5%).
Solid powder with light yellow to yellow appearance.
Molecular formula C31H45N7O4 and molecular weight 579.73.
Structural identifiers available (SMILES and PubChem CID documented).
Supplied in a 10 mg quantity for laboratory research use.
Intended for use in inflammation, cancer, and autoimmune disease research applications.
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AMPA receptor modulator-1 can be activated by glutamate thereby modulating ion channels. purity: 98%
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GLP-1R modulator C5 is an allosteric modulator that enhances GLP-1 binding to GLP-1R through a transmembrane site, with an EC50 of 1.59 ± 0.53 μM. It is intended for research use only.
Allosteric modulator
Enhances GLP-1 binding to GLP-1R
Intended for research use only
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A selective small-molecule research ligand for the 5-HT1A serotonin receptor that also exhibits activity at adrenergic α1 and dopamine D2 receptors. Supplied as a white to off-white solid with supporting analytical documentation (COA and datasheet) for preclinical pharmacology and receptor profiling studies.
High affinity for 5-HT1A receptor, IC50 ≈ 2 nM.
Measured off-target activity at adrenergic α1 and dopamine D2 receptors (IC50 ≈ 10 nM and 40 nM).
Supplied as a stable solid suitable for frozen or refrigerated storage.
Certificate of analysis and purity data available to support assay reproducibility.
Useful as a pharmacological tool for serotonin receptor profiling and CNS research.
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DL-Sulforaphane N-acetyl-L-cysteine is a sulforaphane metabolite used in research as an orally active histone deacetylase (HDAC) inhibitor. It is reported to have an extended half-life and improved blood-brain barrier permeability versus the parent compound, and has been used to study autophagy, HDAC activity, and anticancer mechanisms. Supplied as a high-purity solid for laboratory research.
Orally active HDAC inhibitor and sulforaphane metabolite.
Longer half-life and improved blood-brain barrier permeability compared with parent compound.
Reported to induce autophagy, cell-cycle arrest, and apoptosis in certain cancer cell lines.
High-purity solid suitable for research applications.
Soluble in DMSO; store powder frozen for long-term stability.
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Compounds can either be used as standards and injected individually or a strategy may be employed to pool compounds to allow multiple mixtures to be analyzed per injection.
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GCase modulator-1 (compound 9g) is a quinazoline-derivative small molecule reported to modulate glucocerebrosidase (GCase) activity (reported AC50 = 2.23 μM). It is supplied as a research-grade powder for use in biochemical assays and in vitro studies; reported molecular weight is 338.41 g/mol and reported purity is ~97%.
Modulates GCase (glucosidase) with reported AC50 = 2.23 μM.
Quinazoline-derived small-molecule scaffold suitable for biochemical studies.
Provided as a powder for preparation of assay solutions.
Reported purity approximately 97% and molecular weight 338.41 g/mol.
Intended for research use in vitro; not for human or clinical use.
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GLP-1R modulator L7-028 is a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R). It enhances GLP-1 binding at a transmembrane site (reported EC50 11.01 ± 2.73 μM) and is supplied for research use only as a solid with high analytical purity for in vitro studies of GLP-1R signaling.
Enhances GLP-1 binding via a transmembrane allosteric site.
Reported EC50 11.01 ± 2.73 μM for GLP-1R modulation.
High analytical purity suitable for research (≈99.5%).
Available in small pack sizes for laboratory use.
Molecular formula C24H28N2O3 and molecular weight 392.49.
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Promethazine sulfoxide is a metabolite of the histamine H1 receptor antagonist Promethazine (HY-B1296) It is formed from promethazine by the cytochrome P450 (CYP) isoform CYP2D6
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